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Japanese English Japanese English Access Contact Site Map Message from the Director Mission Organization Organization Chart Research Divisions Administrative Divisions Facilities and Equipment Logo Access Links iPS Cell Research Fund Request for Support Financial Report Contact Principal Investigators Publications Research Overview Protocols on iPS Cells Training Programs Material Distribution Non-Profit Organization Profit Organization CiRA IP iPS Cell Stock for Regenerative Medicine Internship Program Life at CiRA Graduate Program For High School Students FAQ What are iPS cells? For patients For researchers Other Questions iPS MASTER The road to iPS cells (Poster) Photo Galleries Videos News Media Gallery CiRA Reporter Learn More Open Position Closed T-CiRA Joint Program Fellowships Altos-CiRA Research Project Research Activities Research Activities Home　›　Research Activities　›　Principal Investigators　›　Shimpei Gotoh (Professor) Principal Investigators All Dept. of Life Science Frontiers Dept. of Cell Growth and Differentiation Dept. of Clinical Application Uehiro Research Div. for iPS Cell Ethics Dept. of FundamentalCell Technology Dept. of Clinical Application　Shimpei Gotoh (Professor) Research Overview Curriculum Vitae Publications Members Shimpei Gotoh M.D., Ph.D. Lab Website Research Progress in FY2022 Contact: gotoh-g*cira.kyoto-u.ac.jp Please change * to @ Research Overview We are using iPS cells to study the lung, which can be divided into two major specialized areas: the airways and the alveoli. The airways have a function called muco-ciliary clearance to remove foreign substances and pathogens, while the alveoli contribute to gas exchange for bringing oxygen into the body and expelling carbon dioxide. These functions are supported by interactions between various lineage cells. Once disrupted, these interactions can lead to diseases, although they have not been fully understood. We have been tackling the issues starting with the methods of generating airway and alveolar cells from iPS cells. We are now working on two major approaches to convert iPS cell technology into a clinically useful one based on the knowledge we have obtained so far. The first is to understand the mechanism of diseases by recapitulating intractable respiratory diseases in vitro. We hope to find effective diagnostic and therapeutic methods by using human-derived cells, which has been difficult to do with mice and other experimental animals alone. The other is the development of technology to regenerate damaged lungs in vivo. We are working on transplantation study to ask if animal lung function can be restored using human iPS cell-derived lung cells. Lung transplantation has been the ultimate therapeutic strategy for intractable lung diseases when criteria are met, although the shortage of donors has become a serious problem worldwide. Various methods for lung reconstruction are still underway. The salient advantage of iPS cells is their potentials to produce as many cells as needed for research and clinical applications. We hope to present a variety of applications that would lead to useful technologies for new diagnosis and treatment. Principal Investigators Publications Research Overview Protocols on iPS Cells Training Programs Material Distribution Non-Profit Organization For-Profit Organization CiRA IP iPS Cell Stock for Regenerative Medicine About CiRA Message from the Director Mission Organization Facilities and Equipment Logo Access iPS Cell Research Fund Links Contact Research Activities Principal Investigators Publications Research Overview Protocols on iPS Cells Training Programs Material Distribution CiRA IP iPS Stock Cells for Regenerative Medicine Education & Career Internship Program Graduate Program For High school Students Life at CiRA For the Public FAQ iPS MASTER The road to iPS cells Videos News & Events News CiRA Reporter Learn More Media Gallery Jobs Open Positions Closed T-CiRA Altos-CiRA Fellowships Access　|　Contact　|　Site Map Site Policy - Privacy Policy Copyright © Center for iPS Cell Research and Application, Kyoto University. All rights reserved. About CiRA Research Activities Education & Career For the Public News & Events Jobs Access iPS Cell Research Fund Contact